Neurology
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Alzheimer’s Disease
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In small trial led by Dean Ornish, MD, Alzheimer’s patients show better scores on cognitive tests
by
Judy George,
Deputy Managing Editor, MedPage Today
June 11, 2024
Last Updated
June 18, 2024
Intensive lifestyle changes improved cognitive outcomes in a phase II trial of early Alzheimer’s disease.
In Alzheimer’s patients with mild cognitive impairment or early dementia, scores on three measures of cognition and function were significantly better after a 20-week multimodal intervention compared with usual care, reported Dean Ornish, MD, of the University of California San Francisco, and co-authors.
The intervention led to improvements on the Clinical Global Impression of Change (CGIC; P=0.001) and the Clinical Dementia Rating (CDR) global assessment (P=0.037), while the usual-care control group worsened on both measures, the researchers wrote in Alzheimer’s Research & Therapy.
On the CDR-Sum of Boxes (CDR-SB), the intervention group showed slower cognitive decline compared with controls (P=0.032). Scores on the Alzheimer’s Disease Assessment Scale (ADAS-Cog) improved with treatment and worsened in the control group, but the difference was not significant (P=0.053).
Ornish said he was “cautiously optimistic” about the study results. “While our findings are valid and biologically plausible for all the reasons outlined in our research manuscript, all studies need to be replicated,” he told MedPage Today. “I hope our randomized controlled trial will motivate other researchers to conduct larger-scale studies with more diverse populations over longer periods of time.”
“In the meantime, physicians should encourage their patients with Alzheimer’s disease to make these lifestyle changes, as there is a good chance they may improve their cognition and function, as opposed to just slowing down the rate of getting worse,” Ornish added. “They don’t cost anything, and the only side effects are good ones.”
The study is not the first to show positive cognitive outcomes from multimodal interventions. One of the largest was the FINGERS trial, which showed that a 2-year program targeting exercise, diet, cognitive stimulation, and self-monitoring of cardiac and metabolic risk factors had a protective effect on cognition. More recently, the SMARRT trial demonstrated that personal coaching focused on multiple risk factors led to modest cognitive improvements compared with a control group. Unlike the Ornish trial, these studies focused on adults at risk for dementia, not people who had been diagnosed with Alzheimer’s disease.
Ornish and colleagues enrolled 51 Alzheimer’s patients with mild cognitive impairment or early-stage dementia in their trial from September 2018 to June 2022. All participants had plasma amyloid-beta (Aβ)42/40 ratios that strongly suggested Alzheimer’s disease at baseline. The mean age of the group was 73.5 years.
The researchers randomly assigned 26 participants to an intervention group for 20 weeks, and 25 participants to a control group that was asked to not make any lifestyle changes during the trial, after which they would be offered the intervention.
The intervention program had four components: a whole-food, minimally processed, plant-based diet of predominantly fruits, vegetables, whole grains, legumes, and selected supplements; moderate aerobic exercise (such as walking) and strength training for at least 30 minutes a day; stress management including meditation, stretching, breathing, and imagery for 1 hour a day; and online support groups for participants and spouses or study partners for 1-hour sessions three times a week.
The diet had approximately 14% to 18% of its calories as total fat, 16% to 18% as protein, and 63% to 68% as mostly complex carbohydrates. Calories were unrestricted. All meals were sent to each participant’s home twice a week.
At 20 weeks, blood levels of Aβ42/40 improved in the intervention group and worsened in the control group (P=0.003). Microbiome biomarkers improved in the intervention group only (P
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