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Published: 14 May 2024

Immunotherapy

Nature Biotechnology

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A differentiation protocol to produce off-the-shelf natural killer T cells may enable clinical application.

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Fig. 1: AlloCAR-NKT cells derived from hematopoietic stem and progenitor cells target tumor cells and tumor-supportive myeloid cells.

References

Li, Y.-R. et al. Nat. Biotechnol., https://doi.org/10.1038/s41587-024-02226-y (2024).

Bendelac, A., Savage, P. B. & Teyton, L. Annu. Rev. Immunol. 25, 297–336 (2007).

Article 
CAS 
PubMed 

Google Scholar 

Song, L. et al. J. Clin. Invest. 119, 1524–1536 (2009).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Smyth, M. J. et al. Blood 99, 1259–1266 (2002).

Article 
CAS 
PubMed 

Google Scholar 

Shimizu, K., Kurosawa, Y., Taniguchi, M., Steinman, R. M. & Fujii, S. J. Exp. Med. 204, 2641–2653 (2007).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Heczey, A. et al. Nat. Med. 29, 1379–1388 (2023).

Article 
CAS 
PubMed 

Google Scholar 

de Lalla, C. et al. J. Immunol. 186, 4490–4499 (2011).

Article 
PubMed 

Google Scholar 

Ramos, C. A. et al. Transplant. Cell. Ther. 30, S41–S42 (2024).

Article 

Google Scholar 

Yamada, D. et al. Stem Cells 34, 2852–2860 (2016).

Article 
CAS 
PubMed 

Google Scholar 

Li, Y. R. et al. Cell Rep. Med. 2, 100449 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Download references

Author information Authors and Affiliations

Center for Advanced Innate Cell Therapy, Texas Children’s Cancer and Hematology Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

Leonid S. Metelitsa

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Leonid S. Metelitsa.

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The author declares no competing interests.

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Metelitsa, L.S. A milestone method to make natural killer T cells.
Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02243-x

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Published: 14 May 2024

DOI : https://doi.org/10.1038/s41587-024-02243-x

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