Interim ALIGN Data: Atrasentan Cuts Proteinuria in IgA Nephropathy

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Surrogate endpoint of urinary protein-to-creatinine ratio “widely considered to be predictive”

by
Kristen Monaco, Senior Staff Writer, MedPage Today
October 27, 2024

SAN DIEGO — A novel drug significantly reduced IgA nephropathy-related proteinuria, according to interim findings of the ALIGN study.

In the phase III trial, among 270 patients with the rare kidney disorder, those on atrasentan had a 36.1 percentage point (95% CI -44.6 to -26.4, P

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